In 1810, the provincial men's gymnasium was opened in Tobolsk. I.P. Mendeleev worked as a director at the Tobolsk men's gymnasium, P.P. Ershov is associated with this gymnasium, and D.I. Mendeleev and the son of the Decembrist Vladimir Annenkov studied there. Later, the old gymnasium became cramped, and in 1892 a new one was opened in Tobolsk.
In 1913, it was decided to open a teachers' institute in Tobolsk. The Institute was to become the third educational institution in Siberia and the 58th educational institution of its kind in Russia. On November 6, 1916, the Tobolsk Teachers' Institute was inaugurated. Three years later, the first and the last graduates came from the Institute.
In 1939, the Tobolsk Teachers' Institute was revived. Its classrooms are located in the former building of the provincial gymnasium. In 1954, the Tobolsk Teachers' Institute was transformed into a pedagogical one. In 1969, the institute was named after D.I. Mendeleev. In 1980, the Tobolsk Pedagogical Institute moved to a new building on Znamensky Street. In 1987, there were 4 faculties at the Institute, where 1,405 full–time students and 1,280 part-time students studied. The Institute had 15 departments, 136 teachers, including 59 candidates and 1 Doctor of Sciences. In 1989 the institute already had 5 faculties and 23 departments. In 2009, the D.I. Mendeleev Tobolsk State Pedagogical Institute was awarded the status of a socio-pedagogical academy. In 2014, the Tobolsk Pedagogical Institute became a branch of the Tyumen State University.
In the 1970s of the last century, in connection with the launch of the Tobolsk Petrochemical Plant, the largest in the country, there was an urgent need for training personnel for petrochemistry. In 1989, the OTF of the Kazan Institute of Chemical Technology was opened. The recruitment of students for the evening department was conducted in three specialties: "Automation of technological processes and productions", "Machines and apparatuses of chemical industries and enterprises of building materials" and "Chemical technology of synthetic rubber".
In 1991, a full-time department with 50 students was opened. The material base of the faculty is being created during this period: laboratories of chemistry, physics, mechanics, resistance of materials, machine parts, computer technology are being completed, its own library is being opened.
In 1992, the General Technical Faculty was transferred to the Omsk Polytechnic Institute. The Dean of the OTF is invited by the Dean of the Radio Engineering Faculty of the OmPI, Associate Professor, Candidate of Technical Sciences Vladimir Vasilyevich Tokarev. During this period, departments of humanities, general technical and natural sciences were organized, a little later – chemistry and chemical technologies, a computing center.
Since 1990, the faculty has been located in the historical part of the city – the Kremlin, in the Viceroy's Palace. At the beginning of 1993, the Tobolsk Design Institute began designing a complex of buildings for the future institute, at the end of the same year, construction of the university campus began, the first stage of which was commissioned on December 10, 1997 - a four–storey academic building with an area of 11,720 sq.m. Since September 1994, the Tobolsk General Technical Faculty has become a structural subdivision of the Tyumen State Oil and Gas University and AOOT "TNHK". In 1996 OTF was transformed into the Tobolsk branch of TSOGU. In 1993, the first graduation of the General Technical Faculty took place. By Order of the Ministry of General and Vocational Education of the Russian Federation dated February 19, 1998, No. 456, the Tobolsk Branch was renamed the Tobolsk Industrial Institute branch of the Tyumen State Oil and Gas University. V.V. Tokarev was appointed the first director of the Institute, I.G. Mikhailova, E.A. Volkov, A.A. Sultanov were appointed deputy directors, and Yu.I. Nechaev was appointed Dean of the Evening Correspondence Faculty. In 2000 a regional center for training and retraining of specialists has been established. Currently, the Tobolsk Industrial Institute consists of 5 departments: the Department of Humanities, the Department of Natural Sciences, the Department of General Technical Disciplines, the Department of Chemistry and Chemical Technology, the Department of Electric Power Engineering, the teaching staff, of which more than 80 people, 32 of them have academic degrees of Doctor and Candidate of Sciences, more than 15 people are working on doctoral and PhD dissertations, more than 20 laboratories in all disciplines.